Product Name	Recombinant Rabbit Anti-CSF1 Monoclonal Antibody
Cat No.	SLA1044M
Chinese Name	巨噬细胞克隆刺激因子重组兔单抗
Alias	CSF-1; MCSF; PG-M-CSF; BAP025; Csfm; Mhdabap25; op; CSF1_HUMAN; CSF1; M-CSF; Lanimostim; Proteoglycan macrophage colony-stimulating factor (PG-M-CSF); CSF1_MOUSE; CSF1_RAT; colony stimulating factor 1; colony stimulating factor 1 (macrophage); macrophage colony stimulating factor 1;
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	1A11
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human MCSF
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	60 kDa
Subcellular Location	Membrane
Gene ID	1435
Swiss-Prot	P09603
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors. Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.