Product Name	Recombinant Rabbit Anti-CASP1 Monoclonal Antibody
Cat No.	SLA1033M
Chinese Name	切割型半胱天冬酶-1（Asp296）
Alias	ICE; IL1BC; P45; CASP1_HUMAN; CASP1; CASP-1; Interleukin-1 beta convertase (IL-1BC); Interleukin-1 beta-converting enzyme (ICE | IL-1 beta-converting enzyme); 3.4.22.36; IL1BCE; CASP1_MOUSE; CASP1_RAT; caspase 1; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine peptidase; caspase-1; interleukin 1, beta, convertase
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	3D8
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) ELISA (1:5000-10000) IP (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human Caspase-1
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	45 kDa
Subcellular Location	Cytoplasm
Gene ID	834
Swiss-Prot	P29466
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq].
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.