Product Name	Recombinant Rabbit Anti-OPTN Monoclonal Antibody
Cat No.	SLA3500M
Alias	ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP; 4930441O07Rik; OPTN_HUMAN; OPTN; E3-14.7K-interacting protein (FIP-2); Huntingtin yeast partner L; Huntingtin-interacting protein 7 (HIP-7); Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein (TFIIIA-IntP); OPTN_MOUSE; optineurin; glaucoma 1, open angle, E (adult-onset); E3-14.7K-interacting protein; FIP-2; Huntingtin-interacting protein 7; HIP-7; Transcription factor IIIA-interacting protein
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	7G2
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) ELISA (1:5000-10000) IP (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Purification	affinity purified by Protein A
Gene ID	10133
Swiss-Prot	Q96CV9
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.