Product Name	Recombinant Rabbit Anti-ATR (p-S428) Monoclonal Antibody
Cat No.	SLA3402M
Alias	ATR_HUMAN; ATR; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1; 2.7.11.1; FRP1; ATR_MOUSE; Kiaa4069; ATR checkpoint kinase; ataxia telangiectasia and Rad3 related; MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae); Serine/threonine-protein kinase ATR
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	8H8
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Purification	affinity purified by Protein A
Gene ID	545
Swiss-Prot	Q13535
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008],
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.