Product Name	Recombinant Rabbit Anti-GRN Monoclonal Antibody
Cat No.	SLA3268M
Alias	CLN11; FTD2; GEP; GP88; PCDGF; PEPI; PGRN; epithelin; GRN_HUMAN; GRN; Acrogranin; Epithelin precursor; Glycoprotein of 88 Kda (GP88 | Glycoprotein 88); Granulin precursor; PC cell-derived growth factor (PCDGF); Proepithelin (PEPI); GRN_MOUSE; Epithelin/granulin precursor; progranulin; Granulins; Proepithelin; [Cleaved into: Acrogranin; Paragranulin; Granulin-1; Granulin G; Granulin-2; Granulin F; Granulin-3; Granulin B; Granulin-4; Granulin A; Granulin-5; Granulin C; Granulin-6; Granulin D; Granulin-7; Granulin E; ]
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	1D1
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) ELISA (1:5000-10000) IP (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Purification	affinity purified by Protein A
Gene ID	2896
Swiss-Prot	P28799
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.,function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.,function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.,PTM:Granulins are disulfide bridged.,similarity:Belongs to the granulin family.,tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.,
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.