Product Name	Recombinant Rabbit Anti-PPP1R12A Monoclonal Antibody
Cat No.	SLA3149M
Alias	GUBS; M130; MBS; MYPT1; 1200015F06Rik; 5730577I22Rik; D10Ertd625e; M110; MBSP; MYPT1_HUMAN; PPP1R12A; Myosin phosphatase-targeting subunit 1 (Myosin phosphatase target subunit 1); Protein phosphatase myosin-binding subunit; MYPT1_MOUSE; MYPT1_RAT; Protein phosphatase subunit 1M (PP-1M); Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110; protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase 1, regulatory subunit 12A; myosin phosphatase-targeting subunit 1; myosin binding subunit; Myosin phosphatase target subunit 1
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	2D5
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) ELISA (1:5000-10000) IP (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Purification	affinity purified by Protein A
Gene ID	4659
Swiss-Prot	O14974
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosph
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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