Product Name	Recombinant Rabbit Anti-C1QC Monoclonal Antibody
Cat No.	SLA0727M
Chinese Name	补体C1q多肽链C单克隆抗体
Alias	C1Q-C; C1QD3; C1QG; Adib; Ciqc; C1QC_HUMAN; C1QC; C1QC_MOUSE; C1QC_RAT; complement C1q C chain; complement component 1, q subcomponent, gamma polypeptide; complement component 1, q subcomponent, C chain
Host Species	Mouse
Isotype	IgG1, k
Clonality	Monoclonal
Clone No.	1B2
Applications	WB (1:100-1000) IHC-P (1:50-500) IF (1:50-500) ELISA (1:30-3000) IP (1:20-100) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human C1QC
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	26 kDa
Subcellular Location	Secreted
Gene ID	714
Swiss-Prot	P02747
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA, as well as the protein. However, its ability to modulate the interaction of platelets with collagen and immune complexes suggests C1q influences homeostasis as well as other immune activities, and perhaps thrombotic complications resulting from immune injury. Defects in C1q-A, C1q-B and C1q-C cause inactivation of the classical pathway, leading to a rare genetic disorder characterized by lupus-like symptoms.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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