Product Name	Recombinant Rabbit Anti-eIF4EBP1 (p-T70) Monoclonal Antibody
Cat No.	SLA3062M
Chinese Name	磷酸化eIF4E结合蛋白重组兔单抗
Alias	4E-BP1; 4EBP1; BP-1; PHAS-I; 4EBP1_HUMAN; EIF4EBP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1 (PHAS-I); 4EBP1_MOUSE; 4EBP1_RAT; eukaryotic translation initiation factor 4E binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1; eIF4EBP1 (phospho-T70); p-eIF4EBP1; phospho-eIF4EBP1; eIF4EBP1 (phospho-Thr70)
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	6G2
React Species	Human
Applications	WB (1:1000-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human 4E BP1 around the phosphorylation site of T70
Purification	affinity purified by Protein A
Predicted MW.	13 kDa
Observed MW.	17 kDa
Gene ID	1978
Swiss-Prot	Q13541
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.