Product Name	Recombinant Rabbit Anti-TSC2 Monoclonal Antibody
Cat No.	SLA3050M
Chinese Name	磷酸化马铃薯球蛋白(结节性硬化)重组兔单抗
Alias	LAM; PPP1R160; TSC4; Nafld; Tcs2; Rc; TSC2_HUMAN; TSC2; Tuberous sclerosis 2 protein; TSC2_MOUSE; Tuberous sclerosis 2 protein homolog; TSC2_RAT; TSC complex subunit 2; tuberous sclerosis 2; protein phosphatase 1, regulatory subunit 160; TSC2 | Tuberin (phospho-T1462); p-Tuberin; phospho-Tuberin; p-TSC2; TSC2 | Tuberin (phospho-Thr1462)
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	6F3
React Species	Human,Mouse
Applications	WB (1:1000-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human Tuberin around the phosphorylation site of T1462
Purification	affinity purified by Protein A
Predicted MW.	201 kDa
Observed MW.	201 kDa
Subcellular Location	Cytoplasm
Gene ID	7249
Swiss-Prot	P49815
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth.Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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