Product Name	Recombinant Rabbit Anti-CRK (p-Y221) Monoclonal Antibody
Cat No.	SLA1670M
Chinese Name	磷酸化CRK重组兔单抗
Alias	CRKII; p38; Crk-I; Crk-II; Crk-III; Crk3; CrkIII; Crko; c-Crk; CRK_HUMAN; CRK; Proto-oncogene c-Crk; Q96GA9_HUMAN; Q96HJ0_HUMAN; CRK_MOUSE; CRK_RAT; CRK proto-oncogene, adaptor protein; v-crk avian sarcoma virus CT10 oncogene homolog; CRK (phospho-Y221); p-CRK; phospho-CRK; CRK (phospho-Tyr221)
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
React Species	Human
Applications	ICC/IF (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human CRK around the phosphorylation site of Y221
Purification	affinity purified by Protein A
Predicted MW.	34 kDa
Observed MW.	42 kDa
Subcellular Location	Cytoplasm
Gene ID	1398
Swiss-Prot	P46108
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.