Product Name	Recombinant Rabbit Anti-NOTCH4 Monoclonal Antibody
Cat No.	SLA1428M
Chinese Name	跨膜蛋白NOTCH4配体重组兔单抗
Alias	INT3; NOTC4_HUMAN; NOTCH4; Notch 4; hNotch4; notch receptor 4; Notch (Drosophila) homolog 4; Notch homolog 4 (Drosophila)
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
React Species	Human,Mouse
Applications	Flow-Cyt (1:50-100) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human Notch 4
Purification	affinity purified by Protein A
Predicted MW.	210 kDa
Observed MW.	230 kDa
Subcellular Location	Nucleus
Gene ID	4855
Swiss-Prot	Q99466
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.