Product Name	Recombinant Rabbit Anti-SMG1 Monoclonal Antibody
Cat No.	SLA2321M
Chinese Name	丝氨酸/苏氨酸蛋白激酶Smg1重组兔单抗
Alias	61E3.4; ATX; LIP; 2610207I05Rik; 5430435M13Rik; C130002K18Rik; mKIAA0421; SMG1_HUMAN; SMG1; SMG-1; hSMG-1; Lambda/iota protein kinase C-interacting protein (Lambda-interacting protein); Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1; 2.7.11.1; KIAA0421; SMG1_MOUSE; SMG1 nonsense mediated mRNA decay associated PI3K related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans); SMG1 phosphatidylinositol 3-kinase-related kinase; SMG1, nonsense mediated mRNA decay associated PI3K related kinase; phosphatidylinositol 3-kinase-related kinase
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human SMG1
Purification	affinity purified by Protein A
Predicted MW.	411 kDa
Observed MW.	>350 kDa
Gene ID	23049
Swiss-Prot	Q96Q15
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.