Product Name	Recombinant Rabbit Anti-SOCS1 Monoclonal Antibody
Cat No.	SLA0458M
Chinese Name	细胞因子信号传导抑制蛋白1单克隆抗体
Alias	AISIMD; CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP-3; TIP3; Cish7; SOCS1_HUMAN; SOCS1; JAK-binding protein (JAB); STAT-induced STAT inhibitor 1 (SSI-1); Tec-interacting protein 3 (TIP-3); SOCS1_MOUSE; SOCS1_RAT; suppressor of cytokine signaling 1
Host Species	Mouse
Isotype	IgG1
Clonality	Monoclonal
Clone No.	4B2
React Species	Human,Rat
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human Socs 1
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	23 kDa
Subcellular Location	Nucleus
Gene ID	8651
Swiss-Prot	O15524
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor(LIF). Regulates interferon-gamma mediated sensory neuron survival. Implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. High expression in thymus. Lower expression in lung and spleen.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.