Product Name	Rabbit Anti-WNK1 (p-T60) Polyclonal Antibody
Cat No.	SLA0133
Chinese Name	磷酸化赖氨酸缺陷型蛋白激酶1抗体
Alias	HSAN2; HSN2; KDP; PPP1R167; PRKWNK1; PSK; p65; 6430573H23Rik; EG406236; mKIAA0344; WNK1_HUMAN; WNK1; Erythrocyte 65 kDa protein (p65); Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1 (hWNK1); 2.7.11.1; KIAA0344; WNK1_MOUSE; Protein kinase with no lysine 1; WNK1_RAT; WNK lysine deficient protein kinase 1; protein kinase, lysine deficient 1; hereditary sensory neuropathy, type II; protein phosphatase 1, regulatory subunit 167; WNK1 (phospho-T60); p-WNK1; phospho-WNK1; WNK1 (phospho-Thr60)
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Mouse
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated Synthesised phosphopeptide derived from human WNK1 around the phosphorylation site of Thr60
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	251 kDa
Gene ID	65125
Swiss-Prot	Q9H4A3
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	WNK1 controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide sensitive Na/Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. WNK1 has 4 isoforms produced by alternative splicing. WNK1 is widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Defects in WNK1 are a cause of pseudohypoaldosteronism type II (PHAII), an autosomal dominant disease characterized by severe hypertension, hyperkalemia, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.