Product Name	Rabbit Anti-DYRK1A Polyclonal Antibody
Cat No.	SLA0009
Chinese Name	丝氨酸/苏氨酸蛋白激酶MNB抗体
Alias	DYRK; DYRK1; HP86; MNB; MNBH; MRD7; 2310043O08Rik; D16Ertd272e; D16Ertd493e; Gm10783; Mp86; mmb; PSK47; DYR1A_HUMAN; DYRK1A; Dual specificity YAK1-related kinase; Protein kinase minibrain homolog (MNBH | hMNB); 2.7.11.23; 2.7.12.1; DYR1A_MOUSE; Protein kinase minibrain homolog (MNBH); DYR1A_RAT; RP86; dual specificity tyrosine phosphorylation regulated kinase 1A; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ICC/IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human DYRK1A
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	86 kDa
Subcellular Location	Nucleus
Gene ID	1859
Swiss-Prot	Q13627
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A), Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Localized to the nucleus and highly expressed in testis, muscle and the developing nervous system, Dyrk1A, also known as MNB or MNBH, functions to phosphorylate serine, threonine and tyrosine residues on various substrates involved in signaling pathways that regulate cell proliferation. Dyrk1A is a candidate gene for learning defects that are involved in Downs syndrome (DS), suggesting a possible role for Dyrk1A in the development of DS. Four isoforms of Dyrk1A exist due to alternative splicing events.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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