Product Name	Recombinant Rabbit Anti-ERCC8 Monoclonal Antibody
Cat No.	SLA2332M
Chinese Name	科凯恩氏综合症相关蛋白/早衰蛋白CSA重组兔单抗
Alias	CKN1; CSA; UVSS2; 2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik; ERCC8_HUMAN; ERCC8; Cockayne syndrome WD repeat protein CSA; ERCC8_MOUSE; Cockayne syndrome WD repeat protein CSA homolog; ERCC excision repair 8, CSA ubiquitin ligase complex subunit; Cockayne syndrome 1 (classical); excision repair cross-complementing rodent repair deficiency, complementation group 8; excision repair cross-complementation group 8
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	18F8
React Species	Human
Applications	WB (1:500-2000) IP (1:20-50) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human ERCC8
Purification	affinity purified by Protein A
Predicted MW.	44 kDa
Observed MW.	45 kDa
Gene ID	1161
Swiss-Prot	Q13216
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.