Product Name	Recombinant Rabbit Anti-SESN1 Monoclonal Antibody
Cat No.	SLA2237M
Chinese Name	p53调控PA26核蛋白重组兔单抗
Alias	PA26; SEST1; 1110002G11Rik; SESN1_HUMAN; SESN1; p53-regulated protein PA26; 1.11.1.-; SESN1_MOUSE; sestrin 1
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	3F11
React Species	Human
Applications	Flow-Cyt (1:50-100) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human Sestrin 1
Purification	affinity purified by Protein A
Predicted MW.	57 kDa
Observed MW.	70 kDa
Subcellular Location	Nucleus
Gene ID	27244
Swiss-Prot	Q9Y6P5
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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