Product Name	Recombinant Rabbit Anti-RNF2 Monoclonal Antibody
Cat No.	SLA1840M
Chinese Name	环指蛋白2重组兔单抗
Alias	BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B; RING2; RING2_HUMAN; RNF2; Huntingtin-interacting protein 2-interacting protein 3 (HIP2-interacting protein 3); Protein DinG; RING finger protein 1B (RING1b); RING finger protein 2; RING finger protein BAP-1; RING-type E3 ubiquitin transferase RING2; 2.3.2.27; RING2_MOUSE; RING2_RAT
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	1A9
React Species	Human
Applications	Flow-Cyt (1:50-100) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human RING2
Purification	affinity purified by Protein A
Predicted MW.	38 kDa
Observed MW.	38 kDa
Gene ID	6045
Swiss-Prot	Q99496
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.