Product Name	Recombinant Rabbit Anti-HTR2C Monoclonal Antibody
Cat No.	SLA1173M
Chinese Name	5-羟色胺受体2C重组兔单抗
Alias	5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C; 5HT-1C; 5HT2C_HUMAN; HTR2C; 5-HT-2C; 5-hydroxytryptamine receptor 1C (5-HT-1C | 5-HT1C); Serotonin receptor 2C; 5HT2C_RAT; 5ht1c; 5-hydroxytryptamine receptor 2C; 5-hydroxytryptamine (serotonin) receptor 2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	7D11
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human 5 HT2C
Purification	affinity purified by Protein A
Predicted MW.	52 kDa
Observed MW.	72 kDa
Subcellular Location	Membrane
Gene ID	3358
Swiss-Prot	P28335
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq, Jul 2008].
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.