Product Name	Recombinant Rabbit Anti-ADA2 Monoclonal Antibody
Cat No.	SLA1136M
Chinese Name	猫眼综合征染色体候选基因1重组兔单抗
Alias	ADGF; CECR1; IDGFL; PAN; SNEDS; VAIHS; ADA2_HUMAN; ADA2; Cat eye syndrome critical region protein 1; 3.5.4.4; adenosine deaminase 2; cat eye syndrome chromosome region, candidate 1
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	9A3
React Species	Human
Applications	WB (1:500-1000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human ADA2
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	56 kDa
Observed MW.	60 kDa
Subcellular Location	Secreted
Gene ID	51816
Swiss-Prot	Q9NZK5
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	CECR1 is a member of the adenosine and AMP deaminases family. It may act as a growth factor and have adenosine deaminase activity. It is a candidate gene for cat eye syndrome. Two transcript variants encoding distinct isoforms have been identified for this gene. Adenosine deaminase is an enzyme that is present in most tissues and exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. A novel family of growth factors that share sequence similarity to adenosine deaminase has been identified. The cat eye syndrome critical region protein (CECR) family includes CECR1, CECR2, CECR3, CECR4, CECR5, CECR6, CECR7, CECR8 and CECR9. The genes encoding CECR proteins are candidates for Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. CES is characterized by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. CECR family members are widely expressed. Specifically, CECR1 has the highest expression in adult heart, lung, lymphoblasts and placenta. CECR2 is also involved in neurulation and chromatin remodeling. Mutations in the CECR2 gene result in neural tube defects.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.