Product Name	Recombinant Rabbit Anti-UPF1 Monoclonal Antibody
Cat No.	SLA0888M
Chinese Name	ATP依赖解旋酶RENT1重组兔单抗
Alias	HUPF1; NORF1; RENT1; UTF; pNORF1; smg-2; UPF1 RNA helicase and ATPase; regulator of nonsense transcripts 1; UPF1 regulator of nonsense transcripts homolog (yeast); UPF1, RNA helicase and ATPase; UP Frameshift 1; smg-2 homolog, nonsense mediated mRNA decay factor (C. elegans)
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	8B15
React Species	Human
Applications	Flow-Cyt (1ug/Test) ICC/IF (1:100-500) IP (1:10-50) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human Regulator of nonsense transcripts 1
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	124 kDa
Subcellular Location	Cytoplasm
Gene ID	5976
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (1–3). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.