Product Name	Recombinant Rabbit Anti-CLDN18 Monoclonal Antibody
Cat No.	SLA0467M
Chinese Name	紧密连接蛋白18单克隆抗体
Alias	SFTA5; SFTPJ; CLD18_HUMAN; CLDN18; CLD18_MOUSE; D3ZLY1_RAT; claudin 18; surfactant associated protein J
Host Species	Mouse
Isotype	IgG1, Kappa
Clonality	Monoclonal
Clone No.	7A12
React Species	Human
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human Claudin-18
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	28 kDa
Subcellular Location	Membrane
Gene ID	51208
Swiss-Prot	P56856
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (6).
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.