Product Name	Recombinant Rabbit Anti-PSEN1 Monoclonal Antibody
Cat No.	SLA1797M
Chinese Name	早老素蛋白1重组兔单抗
Alias	ACNINV3; AD3; CMD1U; FAD; PS-1; PS1; PSNL1; S182; Ad3h; PSN1_HUMAN; PSEN1; Protein S182; 3.4.23.-; PSN1_MOUSE; PSN1_RAT; presenilin 1; Alzheimer disease 3; familial Alzheimer Disease
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	5D12
React Species	Human,Mouse,Rat
Applications	IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human Presenilin 1
Purification	affinity purified by Protein A
Predicted MW.	53 kDa
Observed MW.	28 kDa
Subcellular Location	Cytoplasm
Gene ID	5663
Swiss-Prot	P49768
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Requires the presence of the other members of the gamma-secretase complex for protease activity.Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Presenilin 1 Monoclonal Antibody, Unconjugated(SLA1797M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 2. Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Presenilin 1 Monoclonal Antibody, Unconjugated(SLA1797M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 3. Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Presenilin 1 Monoclonal Antibody, Unconjugated(SLA1797M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 4. Paraformaldehyde-fixed, paraffin embedded Human Glioma; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Presenilin 1 Monoclonal Antibody, Unconjugated(SLA1797M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 5. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Presenilin 1 Monoclonal Antibody, Unconjugated (SLA1797M) at 1:200 overnight at 4°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (Red, SL0295G-BF594), DAPI (blue, C02-04002) was used to stain the cell nuclei.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.