Product Name	Recombinant Rabbit Anti-TRPM7 Monoclonal Antibody
Cat No.	SLA1717M
Chinese Name	瞬时受体电位离子通道蛋白7重组兔单抗（M亚家族）
Alias	ALSPDC; CHAK; CHAK1; LTRPC7; LTrpC-7; TRP-PLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik; Ltpr7; TRPPLIK; TRPM7_HUMAN; TRPM7; Channel-kinase 1; Long transient receptor potential channel 7 (LTrpC-7 | LTrpC7); 2.7.11.1; TRPM7_MOUSE; Transient receptor potential-phospholipase C-interacting kinase (TRP-PLIK); TRPM7_RAT; transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel, subfamily M, member 7
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	3E3
React Species	Human,Mouse,Rat
Applications	IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human TRPM7
Purification	affinity purified by Protein A
Predicted MW.	213 kDa
Observed MW.	213 kDa
Subcellular Location	Membrane
Gene ID	54822
Swiss-Prot	Q96QT4
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium.Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with TRPM7 Monoclonal Antibody, Unconjugated(SLA1717M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 2. Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with TRPM7 Monoclonal Antibody, Unconjugated(SLA1717M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 3. Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with TRPM7 Monoclonal Antibody, Unconjugated(SLA1717M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 4. Paraformaldehyde-fixed, paraffin embedded Human Lung Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with TRPM7 Monoclonal Antibody, Unconjugated(SLA1717M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 5. Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with TRPM7 Monoclonal Antibody, Unconjugated(SLA1717M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 6. Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TRPM7 Monoclonal Antibody, Unconjugated (SLA1717M) at 1:200 overnight at 4°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (Red, SL0295G-BF594), DAPI (blue, C02-04002) was used to stain the cell nuclei.
Figure 7. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TRPM7 Monoclonal Antibody, Unconjugated (SLA1717M) at 1:200 overnight at 4°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (Red, SL0295G-BF594), DAPI (blue, C02-04002) was used to stain the cell nuclei.	Figure 8. Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TRPM7 Monoclonal Antibody, Unconjugated (SLA1717M) at 1:200 overnight at 4°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (Red, SL0295G-BF594), DAPI (blue, C02-04002) was used to stain the cell nuclei.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.