Product Name	Recombinant Rabbit Anti-SNCA Monoclonal Antibody
Cat No.	SLA0527M
Chinese Name	核突触蛋白单克隆抗体
Alias	NACP; PARK1; PARK4; PD1; alpha-Syn; alphaSYN; SYUA_HUMAN; SNCA; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor (NACP); SYUA_MOUSE; Syn; SYUA_RAT; synuclein alpha; Parkinson disease (autosomal dominant, Lewy body) 4; synuclein, alpha (non A4 component of amyloid precursor); non A4 component of amyloid precursor; alpha-synuclein; α-synuclein
Host Species	Mouse
Isotype	IgG
Clonality	Monoclonal
Clone No.	8F7
React Species	Human
Applications	WB (1:500-2000) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human Alpha-synuclein
Purification	affinity purified by Protein A
Predicted MW.	14 kDa
Observed MW.	16 kDa
Subcellular Location	Nucleus
Gene ID	6622
Swiss-Prot	P37840
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. 25 ug total protein per lane of various lysates (see on figure) probed with Alpha-synuclein monoclonal antibody, unconjugated (SLA0527M) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.