Product Name	Recombinant Rabbit Anti-IRAK1 Monoclonal Antibody
Cat No.	SLA1193M
Chinese Name	白介素-1受体相关激酶1重组兔单抗
Alias	IRAK; pelle; IRAK-1; IRAK1-S; IRAK1b; Il1rak; Plpk; mPLK; RGD1563841; IRAK1_HUMAN; IRAK1; 2.7.11.1; IRAK1_MOUSE; Pelle-like protein kinase (mPLK); interleukin 1 receptor associated kinase 1
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	15G13
React Species	Human
Applications	WB (1:1000-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human IRAK1
Purification	affinity purified by Protein A
Predicted MW.	78 kDa
Observed MW.	75 kDa
Subcellular Location	Nucleus
Gene ID	3654
Swiss-Prot	P51617
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. 25 ug total protein per lane of various lysates (see on figure) probed with IRAK monoclonal antibody, unconjugated (SLA1193M) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

Ordering & shipping

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