Product Name	Rabbit Anti-BDKRB1 Polyclonal Antibody
Cat No.	SLA0055
Chinese Name	缓激肽B1受体抗体
Alias	B1BKR; B1R; BKB1R; BKR1; BRADYB1; BKRB1_HUMAN; BDKRB1; BK-1 receptor; bradykinin receptor B1
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human BDKRB1
Purification	affinity purified by Protein A
Concentration	1mg/1ml
Predicted MW.	40 kDa
Observed MW.	60 kDa
Gene ID	623
Swiss-Prot	P46663
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G-protein coupled receptors, named B1 and B2. The B2 receptor is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Sample: Lane 1: Human U87MG cell lysates Lane 2: Human LOVO cell lysates Lane 3: Human HUVEC cell lysates Lane 4: Human K562 cell lysates Lane 5: Human U251 cell lysates Lane 6: Human A549 cell lysates Lane 7: Human HeLa cell lysates Primary: Anti-BDKRB1 (SLA0055) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 60 kDa

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.