Product Name	Recombinant Rabbit Anti-SFTPC Monoclonal Antibody
Cat No.	SLA0911M
Chinese Name	肺表面活性蛋白C重组兔单抗
Alias	BRICD6; PSP-C; SFTP2; SMDP2; SP-C; SP5; SPC; Sftp-2; pro-SpC; PSPC_HUMAN; SFTPC; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); PSPC_MOUSE; surfactant protein C; surfactant, pulmonary-associated protein C; BRICHOS domain containing 6
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	11C1
React Species	Human,Mouse,Rat
Applications	WB (1:1000-2000) IHC-P (1:500-2000) IHC-F (1:500-2000) IF (1:500-2000) Flow-Cyt (1:100-200) ICC/IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human SFTPC
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	21 kDa
Subcellular Location	Extracellular
Gene ID	6440
Swiss-Prot	P11686
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Paraformaldehyde-fixed, paraffin embedded Mouse Lung; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SFTPC Monoclonal Antibody, Unconjugated (SLA0911M) at 1:500 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 2. Paraformaldehyde-fixed, paraffin embedded Human Lung; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SFTPC Monoclonal Antibody, Unconjugated (SLA0911M) at 1:500 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 3. Paraformaldehyde-fixed, paraffin embedded Human Lung Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SFTPC Monoclonal Antibody, Unconjugated (SLA0911M) at 1:500 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 4. Paraformaldehyde-fixed, paraffin embedded Rat Lung; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SFTPC Monoclonal Antibody, Unconjugated (SLA0911M) at 1:500 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 5. (Negative control) Paraformaldehyde-fixed, paraffin embedded Mouse Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SFTPC Monoclonal Antibody, Unconjugated (SLA0911M) at 1:500 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 6. (Negative control) Paraformaldehyde-fixed, paraffin embedded Rat Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SFTPC Monoclonal Antibody, Unconjugated (SLA0911M) at 1:500 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 7. (Negative control) Paraformaldehyde-fixed, paraffin embedded Human Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with SFTPC Monoclonal Antibody, Unconjugated (SLA0911M) at 1:500 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.