Product Name	Anti-NCR1/PE-Cy5
Chinese Name	PE-Cy5标记的细胞毒性受体NK-p46抗体
Alias	Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN.
Research Area	Tumour
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,Mouse
Applications	Flow-Cyt=2ug/Test,IF=1:100-500 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	31kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NCR1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 5M PB, pH 7.5.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 1M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Subunit: Interacts with CD247 and FCER1G. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed by both resting and activated NK cells. Similarity: Belongs to the natural cytotoxicity receptor (NCR) family. Contains 2 Ig-like (immunoglobulin-like) domains. Database links: Entrez Gene: 9437 Human Entrez Gene: 17086 Mouse Entrez Gene: 117547 Rat Omim: 604530 Human SwissProt: O76036 Human SwissProt: Q8C567 Mouse SwissProt: Q9Z0H5 Rat Unigene: 97084 Human Unigene: 240231 Mouse Unigene: 30049 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. NKp46 is a very important natural cytotoxicity receptor that plays a key role in natural killing. The cytotoxic receptor family (NCRs) mainly includes NKp46, NKp44, and NKp30, among which NKp46 and NKp30 are expressed on all resting and activated NK cells, while NKp44 is selectively expressed on activated NK cells. Binding (cross-linking) of ligand molecules on target cells with NCRs triggers NK cell activation, leading to lysis of target cells and production of large amounts of cell factors. It has now been confirmed that NKp46 and NKp44 can recognize the viral ligand molecule hemagglutinin, while NKp46 can recognize acetylated sulfated polysaccharides on tumor cells.