Product Name	BMP2
Chinese Name	骨形态发生蛋白2抗体
Alias	Bone morphogenetic protein 2; BMP 2; BMP 2A; BMP2A; BMP-2; BMP2_HUMAN.
literatures	Specific References (39) | SL1012R has been referenced in 39 publications. [IF=15.153] Haojun Liang. et al. A Bone-Penetrating Precise Controllable Drug Release System Enables Localized Treatment of Osteoporotic Fracture Prevention via Modulating Osteoblast-Osteoclast Communication. SMALL. 2023 Mar;:2207195 IHC ; Rat. PubMed:36971278 [IF=11.322] Chengzhong Xu. et al. Microenvironment responsive hypoxia-mimetic DFO composite hydrogel for on-demand neovascularization to promote tendon-to-bone healing. COMPOS PART B-ENG. 2023 Apr;:110726 IF ; Human,Rat,Mouse. PubMed:10.1016/j.compositesb.2023.110726 [IF=10.652] Zhiwei Jiangaet al. An effective light activated TiO2 nanodot platform for gene delivery within cell sheets to enhance osseointegration. WB ; Human. PubMed:10.1016/j.cej.2020.126170 [IF=9.417] Bangbang Liang. et al. Proportion-dependent osteogenic activity of electrospun nano-hydroxyapatite/polylactic acid fiber membrane in vitro and in vivo. MATER DESIGN. 2022 Jul;219:110834 WB ; Rat. PubMed:10.1016/j.matdes.2022.110834 [IF=8.38] Naeem, A. S., et al. "AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation." Cell Death & Differentiation (2015). WB ; Rat. PubMed:26045045 [IF=8.352] Ye Hea et al. Improved osteointegration by SEW2871-encapsulated multilayers on micro-structured titanium via macrophages recruitment and immunomodulation. Applied Materials Today 20 (2020) 100673 IHC ; Rat. PubMed:10.1016/j.apmt.2020.100673 [IF=8.071] Yifan Pan. et al. Disturbance in transcriptomic profile, proliferation and multipotency in human mesenchymal stem cells caused by hexafluoropropylene oxides. Environ Pollut. 2022 Jan;292:118483 IF ; Human. PubMed:34763017 [IF=6.064] Yu Hedong. et al. Improved repair of rabbit calvarial defects with hydroxyapatite/chitosan/polycaprolactone composite scaffold-engrafted EPCs and BMSCs. FRONT BIOENG BIOTECH. 2022 Aug;0:1275 WB ; Rabbit. PubMed:35992335 [IF=5.58] Zhang, Jing, et al. "Combination of simvastatin, calcium silicate/gypsum, and gelatin and bone regeneration in rabbit calvarial defects." Scientific Reports 6 (2016): 23422. IHC-P ; Rabbit. PubMed:26996657 [IF=5.546] Taiga Ono. et al. Generation of biohybrid implants using a multipotent human periodontal ligament cell line and bioactive core materials. 2021 Feb 19 IF ; Human. PubMed:33604904 [IF=5.395] Yuanchao Zhu. et al. Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway. ACS BIOMATER-SCI ENG. 2023;XXXX(XXX):XXX-XXX IHC ; Rat. PubMed:37200162 [IF=5.08] Hsieh MK et al. BMP-2 gene transfection of bone marrow stromal cells to induce osteoblastic differentiation in a rat calvarial defect model.Mater Sci Eng C Mater Biol Appl. 2018 Oct 1;91:806-816. IHC-P ; Rat. PubMed:30033316 [IF=4.225] Shiyi Huang. et al. Transforming Growth Factor-β3/Recombinant Human-like Collagen/Chitosan Freeze-Dried Sponge Primed With Human Periodontal Ligament Stem Cells Promotes Bone Regeneration in Calvarial Defect Rats. Front Pharmacol. 2021; 12: 678322 IHC ; Rat. PubMed:33967817 [IF=4.101] Yu Guo. et al. RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF‑β1/Smad pathway. Int J Mol Med. 2021 Aug;48(2):1-13 WB ; Sheep. PubMed:34132357 [IF=3.934] Li Zhilang. et al. Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids. Endocrinology. 2020 Nov;161(11): PubMed:32976565 [IF=3.616] Lv N et al. The roles of bone morphogenetic protein 2 in perfluorooctanoic acid induced developmental cardiotoxicity and l-carnitine mediated protection.Toxicol Appl Pharmacol. 2018 Aug 1;352:68-76. WB&IHC ; Chicken. PubMed:29800642 [IF=3.573] Liu, Jie. et al. Phosphorylated PAMAM dendrimers: an analog of dentin non-collagenous proteins, enhancing the osteo/odontogenic differentiation of dental pulp stem cells. 2021 Sep 13 WB ; human. PubMed:34515858 [IF=3.378] Song, Yanqiu. et al. Iron overload impairs renal function and is associated with vascular calcification in rat aorta. BIOMETALS. 2022 Sep;:1-15 WB ; Rat. PubMed:36178540 [IF=3.375] Gao R et al. Three-dimensional-printed titanium alloy porous scaffold combined with trans-cinnamaldehyde for repairing osteonecrosis of the femoral head in a dog model. Am J Transl Res . 2020 Mar 15;12(3):1070-1079. IHC ; beagle dogs. PubMed:32269735 [IF=3.246] Shimin Hao. et al. Evaluation of Biodegradable Alloy Fe30Mn0.6N in Rabbit Femur and Cartilage through Detecting Osteogenesis and Autophagy. BIOMED RES INT. 2023 Jan 18;2023:3626776 IHC ; Rabbit. PubMed:36714031 [IF=3.161] Yılmaz, Birtan Tolga. et al. In vivo efficacy of low-level laser therapy on bone regeneration. Laser Med Sci. 2022 Jan;:1-8 IHC ; Rabbit. PubMed:35022870 [IF=2.86] Kishi, Yuta, et al. "PARP Inhibitor PJ34 Suppresses Osteogenic Differentiation in Mouse Mesenchymal Stem Cells by Modulating BMP-2 Signaling Pathway."International Journal of Molecular Sciences 16.10 (2015): 24820-24838. WB ; Mouse. PubMed:26492236 [IF=2.784] Chen X et al. Modulation of proliferation and differentiation of gingiva‑derived mesenchymal stem cells by concentrated growth factors: Potential implications in tissue engineering for dental regeneration and repair. Send to Int J Mol Med. 2019 Apr 24. WB ; Human. PubMed:31017269 [IF=2.768] Li Y et al. Sulfonated chitosan oligosaccharide alleviates the inhibitory effect of basic fibroblast growth factor on osteogenic differentiation of human periodontal ligament stem cells. J Periodontol. 2019 Oct 1. WB ; Human. PubMed:31573683 [IF=2.65] Kai Wang. et al. Network Pharmacological Analysis and Animal Experimental Study on Osteoporosis Treatment with GuBen-ZengGu Granules. EVID-BASED COMPL ALT. 2023 Jan 12;2023:9317557 WB ; Rat. PubMed:36686973 [IF=2.639] Jiarong Yanget al. Effects of Different Doses of Calcium on the Mitochondrial Apoptotic Pathway and Rho/ROCK Signaling Pathway in the Bone of Fluorosis Rats. Biol Trace Elem Res . 2020 Jul 25. IHC ; rat. PubMed:32710350 [IF=2.38] Zhu, Wenjing, et al. "Effect of PI3K/Akt Signaling Pathway on the Process of Prostate Cancer Metastasis to Bone." Cell Biochemistry and Biophysics (2015): 1-7. WB ; Human. PubMed:22870197 [IF=2.341] Diao S et al. IGF2 enhanced the osteo‐/dentinogenic and neurogenic differentiation potentials of stem cells from apical papilla. J Oral Rehabil. 2019 Jul 10. WB ; Human. PubMed:31291686 [IF=2.31] Wei B et al. Osteoprotegerin/bone morphogenetic protein 2 combining with collagen sponges on tendon-bone healing in rabbits. J Bone Miner Metab. 2020 Jan 24. ELISA ; Rabbit. PubMed:31980897 [IF=2.24] Wu, Mei, et al. "Expression analysis of BMP2, BMP5, BMP10 in human colon tissues from Hirschsprung disease patients." Int J Clin Exp Pathol 7.2 (2014): 529-536. IHC-P,WB ; Human. PubMed:24551273
Research Area	Cell biology immunology Developmental biology Neurobiology Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat (predicted: Human, Rabbit, Sheep, Cow, Chicken, Dog, Horse)
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Theoretical molecular weight	13/44kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BMP2: 283-365/396
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis. Function: Induces cartilage and bone formation. Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN. Subcellular Location: Secreted. Tissue Specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine. Similarity: Belongs to the TGF-beta family. SWISS: P12643 Gene ID: 650 Database links: Entrez Gene: 650 Human Entrez Gene: 12156 Mouse Entrez Gene: 29373 Rat Omim: 112261 Human SwissProt: P12643 Human SwissProt: P21274 Mouse SwissProt: P49001 Rat Unigene: 73853 Human Unigene: 103205 Mouse Unigene: 90931 Rat Neural stem cell marker BMP-2 mainly recruits and induces differentiation of undifferentiated mesenchymal cells and cells of the bone lineage. In early bone formation, BMP-2 not only recruits undifferentiated mesenchymal cells to bone-forming centres and induces their differentiation into bone lineage cells, but can also induce reversal of fibroblasts, myoblasts and bone marrow stromal cells into bone lineage cells. The main process is: increasing or inhibiting the secretion of certain specific proteins in these cells, causing fibroblast differentiation into osteoblasts and rapid differentiation of myoblasts into hypertrophic chondrocytes, and promoting matrix calcification. For osteoblasts, BMP-2 maintains their specific cell phenotype, induces an increase in osteoblast markers and promotes extracellular matrix calcification. In the late stage of bone formation, BMP-2 also acts as an osteoclast differentiation factor, directly or indirectly stimulating osteoclast differentiation together with other supporting osteoclast differentiation factors, and participates in bone remodelling.
Product Picture	Figure 1. 25 ug total protein per lane of various lysates (see on figure) probed with BMP2 polyclonal antibody, unconjugated (SL1012R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min