Product Name	Density Regulated Protein
Chinese Name	密度调节蛋白抗体
Alias	denr; DENR_HUMAN; Density regulated protein; Density-regulated protein; DRP; DRP1; DRP1 protein; Protein DRP1; SMAP-3; SMAP3; Smooth muscle cell associated protein 3; Smooth muscle cell-associated protein 3.
literatures	Specific References (1) | SL14276R has been referenced in 1 publications. [IF=5.168] Ruonan Wang. et al. The role of mitochondrial dynamics imbalance in hexavalent chromium-induced apoptosis and autophagy in rat testis. CHEM-BIOL INTERACT. 2023 Apr;374:110424 WB ; Rat. PubMed:36849043
Research Area	Tumour Transporter Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Density Regulated Protein: 51-150/198
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008] Function: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. Tissue Specificity: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney. Similarity: Belongs to the DENR family. Contains 1 SUI1 domain. SWISS: O43583 Gene ID: 8562 Database links: Entrez Gene: 8562 Human Entrez Gene: 771794 Chicken Entrez Gene: 614238 Cow Entrez Gene: 68184 Mouse Entrez Gene: 360806 Rat Entrez Gene: 444615 Xenopus laevis Omim: 604550 Human SwissProt: Q5ZJ39 Chicken SwissProt: Q2HJ47 Cow SwissProt: O43583 Human SwissProt: Q9CQJ6 Mouse SwissProt: Q6GLZ1 Xenopus laevis SwissProt: Q6DFN7 Xenopus tropicalis Unigene: 22393 Human Unigene: 28549 Mouse Unigene: 7540 Xenopus laevis
Product Picture	Sample: Heart (Mouse) Lysate at 40 ug Brain (Mouse) Lysate at 40 ug Primary: Anti-Density Regulated Protein (SL14276R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 22 kD Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Density Regulated Protein) Polyclonal Antibody, Unconjugated (SL14276R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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