Product Name	DEPDC1B/BRCC3
Chinese Name	乳腺癌细胞3抗体
Alias	BRCC3; Breast cancer cell 3; DEP domain containing 1B; DEP domain containing protein 1B; FLJ11252; DEP1B_HUMAN; HBV X transactivated gene 8 protein; HBV X-transactivated gene 8 protein; HBV XAg-transactivated protein 8; HBxAg transactivated protein 1; OTTHUMP00000122605; OTTHUMP00000221973; XTP1; XTP8.
literatures	Specific References (3) | SL14278R has been referenced in 3 publications. [IF=3.784] Z-D Liu. et al. Aberrantly high DEPDC1B expression leads to poor prognosis in patients with lower-grade gliomas. EUR REV MED PHARMACO. 2022 Nov;26(21):7813-7826 IHC ; Human. PubMed:36394729 [IF=1.664] Ma et al. High levels of glioma tumor suppressor candidate region gene 1 predicts a poor prognosis for prostate cancer. (2018) Oncol.Lett. 16:6749-6755 IHC ; Human. PubMed:30405818 [IF=1.39] Bai, Shoumin, et al. "High levels of DEPDC1B predict shorter biochemical recurrence‑free survival of patients with prostate cancer." Oncology Letters. WB, IHC-P ; Human. PubMed:29163701
Research Area	Tumour Cell biology Signal transduction G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human (predicted:Mouse,Rat,Cow,Rabbit)
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	62kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DEPDC1B/BRCC3: 451-529/529
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GTPase activator activity. biological process: intracellular signaling cascade Subcellular Location: intracellular Similarity: Contains 1 DEP domain. Contains 1 Rho-GAP domain. SWISS: Q8WUY9 Gene ID: 55789 Database links: Entrez Gene: 55789 Human SwissProt: Q8WUY9 Human
Product Picture	Sample: Lane 1: Human HepG2 cell lysates Lane 2: Human MCF-7 cell lysates Primary: Anti-DEPDC1B/BRCC3 (SL14278R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 62 kDa Observed band size: 68 kDa Tissue/cell: human brain glioma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 1M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-BRCC3 Polyclonal Antibody, Unconjugated(SL14278R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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