Product Name	IRAK2
Chinese Name	白介素-1受体相关激酶2抗体
Alias	Interleukin 1 receptor associated kinase like 2; il1rak2; Interleukin 1 receptor associated kinase 2; Interleukin-1 receptor-associated kinase-like 2; IRAK 2; IRAK-2; Irak2; IRAK2_HUMAN; MGC150550.
Research Area	Cell biology immunology Signal transduction Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	69kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IRAK2: 21-150/625
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B. Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Subunit: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Tissue Specificity: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Contains 1 death domain. Contains 1 protein kinase domain. SWISS: O43187 Gene ID: 3656 Database links: Entrez Gene: 3656 Human Entrez Gene: 108960 Mouse Entrez Gene: 362418 Rat Omim: 603304 Human SwissProt: O43187 Human SwissProt: Q8CFA1 Mouse SwissProt: Q5R810 Orangutan SwissProt: Q4QQS0 Rat Unigene: 449207 Human Unigene: 152142 Mouse Unigene: 17123 Rat Kinases and Phosphatases（Kinases and Phosphatases）

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