Product Name	EHD2
Chinese Name	EHD2蛋白抗体
Alias	EH domain containing 2; EH domain containing 3; EH domain containing protein 2; EH domain-containing protein 2; EHD 2; Ehd2; EHD2_HUMAN; EHD3; FLJ96617; PAST 2; PAST homolog 2; PAST2.
literatures	Specific References (1) | SL14526R has been referenced in 1 publications. [IF=5.177] Junqiang Li. et al. Ese-3 contributes to colon cancer progression by downregulating EHD2 and transactivating INPP4B. Am J Cancer Res. 2021; 11(1): 92–107 WB,IHC ; Human. PubMed:33520362
Research Area	Cell biology Binding protein Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EHD2: 451-543/543
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008] Function: Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP. Subcellular Location: Cell membrane. Endosome membrane. Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Tissue Specificity: Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle. Similarity: Contains 1 EF-hand domain. Contains 1 EH domain. SWISS: Q9NZN4 Gene ID: 30846 Database links: Entrez Gene: 30846 Human Entrez Gene: 538348 Cow Entrez Gene: 259300 Mouse Entrez Gene: 361512 Rat Omim: 605890 Human SwissProt: Q9NZN4 Human SwissProt: Q8BH64 Mouse SwissProt: Q4V8H8 Rat Unigene: 631554 Human Unigene: 138215 Mouse Unigene: 438817 Mouse Unigene: 16016 Rat