Product Name	ROR gamma T
Chinese Name	维甲酸相关孤儿受体γt抗体
Alias	RORG_HUMAN; Nuclear receptor ROR-gamma; ROR Gamma; NR1F3; RZRG; TOR; IMD42; RZR-GAMMA; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; ROR gamma T [Mus musculus]; nuclear receptor ROR-gamma isoform 2; RORgT;
literatures	Specific References (6) | SL23110R has been referenced in 6 publications. [IF=8.786] Mengyuan Zhu. et al. Insulin-binding protein-5 down-regulates the balance of Th17/Treg.. FRONT IMMUNOL. 2022 Nov;13:1019248-1019248 IHC ; Mouse. PubMed:36389828 [IF=6.656] Yuhan Wu. et al. DiHuangYin decoction protects dopaminergic neurons in a Parkinson's disease model by alleviating peripheral inflammation. PHYTOMEDICINE. 2022 Oct;105:154357 IF, WB ; Mouse. PubMed:35933898 [IF=5.085] Wang Ning. et al. CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model. Front Immunol. 2020 Aug;11:1883 IHC ; Mouse. PubMed:32983109 [IF=2.65] Ye Tian. et al. The Mitigatory Effect of Shen-Qi Compound on the Diabetic Thoracic Aortic Complications through Inhibiting the Inflammatory Microenvironment by miR-223-3p/RBP-J/IRF8 Axis. EVID-BASED COMPL ALT. 2022 Sep 28;2022:6686931 WB ; Rat. PubMed:36212957 [IF=2.63] Zhang Peng. et al. Study on the Mechanism of Bu-Shen-He-Mai Granules in Improving Renal Damage of Ageing Spontaneously Hypertensive Rats by Regulating Th17 Cell/Tregs Balance. EVID-BASED COMPL ALT. 2022;2022:8315503 IF ; Rat. PubMed:35502169 [IF=1.785] Peng S et al. Poly(ADP‑ribose) polymerase‑1 inhibitor ameliorates dextran sulfate sodium‑induced colitis in mice by regulating the balance of Th17/Treg cells and inhibiting the NF‑κB signaling pathwayExp Ther Med.2021 Feb;21(2):134. WB ; Mouse. PubMed:33376516
Research Area	immunology Signal transduction transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,Rat (predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit)
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,Flow-Cyt=1ug/test （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse ROR gamma T: 1-100/516
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. SWISS: P51449 Gene ID: 19885 Database links: Entrez Gene: 6097 Human Entrez Gene: 19885 Mouse Entrez Gene: 368158 Rat Omim: 602943 Human SwissProt: P51449 Human SwissProt: P51450 Mouse Unigene: 256022 Human Unigene: 607993 Human Unigene: 4372 Mouse
Product Picture	Figure 1. Sample: Lane1: Mouse Muscle Lysates Lane2: Rat Muscle Lysates Primary: Anti-ROR Gamma (SL23110R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 57 kD Observed band size: 57 kD Figure 2. Paraformaldehyde-fixed, paraffin embedded (Rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ROR gamma T) Polyclonal Antibody, Unconjugated (SL23110R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining Figure 3. Paraformaldehyde-fixed, paraffin embedded (Rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ROR gamma T) Polyclonal Antibody, Unconjugated (SL23110R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining