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Mouse Anti-NGAL/Lipocalin 2 antibody

Mouse Anti-NGAL/Lipocalin 2 antibody

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  • Cat NO.:V0002
  • Product Spec:50ul
  • Clonality:Monoclonal
  • 100ul:$376
  • Species:Mouse
  • Price:$236
  • Total:
  • Quantity:
  • Manual

Goods Brief:

Product Name NGAL/Lipocalin 2
Chinese Name 脂质运载蛋白单克隆抗体
Alias Lipocalin 2; Neutrophil Gelatinase associated Lipocalin; 25 kDa alpha 2 microglobulin related subunit of MMP9; Alpha 2 microglobulin related protein; HGNC:6526; HNL; Lcn 2; LCN-2; Lcn2; Neutrophil gelatinase associated lipocalin precursor; NGAL; Oncogene 24p3; P25; SV40 induced 24P3 protein. 24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Migration stimulating factor inhibitor; MSFI; Neutrophil gelatinase associated lipocalin precursor; Neutrophil gelatinase-associated lipocalin; NGAL_HUMAN; Oncogenic lipocalin 24p3; Siderocalin; siderocalin LCN2; SV40 induced 24P3 protein.  
Organism Species Mouse
Clonality Monoclonal
Clone NO 3G9L
React Species (predicted: Human, )
Applications ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 20kDa
Cellular localization Secretory protein 
Form Liquid
Concentration ≥1mg/ml
immunogen Recombinant human NGAL 
Lsotype IgG
Purification affinity purified by Protein A
Buffer 0.01M TBS(pH7.4) with 0.1% Proclin300l.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Lipocalin 2 is a member of the lipocalin family which encompass more than 25 members (including proteins like retinol binding protein, a1 microglobulin, b lactoglobulin, apolipoprotein D and odorant binding protein). The members of the lipocalin family are characterized by their ability to bind small lipophilic substances in their hydrophobic core, and thereby serve as transporters of substances.

Function:
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Subunit:
Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9.

Subcellular Location:
Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.

Tissue Specificity:
Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.

Similarity:
Belongs to the calycin superfamily. Lipocalin family.

SWISS:
P80188

Gene ID:
3934

Database links:

Entrez Gene: 3934 Human

Entrez Gene: 16819 Mouse

Entrez Gene: 170496 Rat

Omim: 600181 Human

SwissProt: P80188 Human

SwissProt: P11672 Mouse

SwissProt: P30152 Rat

Unigene: 204238 Human

Unigene: 9537 Mouse

Unigene: 11303 Rat


 
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