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Rabbit Anti-IkB beta/FITC Conjugated antibody

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  • Cat NO.:SL10246R-FITC
  • Product Spec:100ul
  • Clonality:Polyclonal
  • 100ul:496.00$
  • Price:$496
  • Total:
  • Quantity:
  • Manual

Goods Brief:

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Product Name Anti-IkB beta/FITC
Chinese Name FITC标记的NF-kappa-B抑制子beta抗体
Alias I kappa B beta; I-kappa-B-beta; IkappaBbeta; IKB beta; IkB-B; IkB-beta; IKBB; IKBB_HUMAN; IkBbeta; NF kappa BIB; NF-kappa-B inhibitor beta; NF-kappa-BIB; Nfkbib; Thyroid receptor interacting protein 9; Thyroid receptor-interacting protein 9; TR interacting protein 9; TR-interacting protein 9; TRIP-9; TRIP9.  
Organism Species Rabbit
Clonality Polyclonal
React Species Human, Mouse, Rat, Dog, Pig, Horse, 
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 38kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human IkB beta
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011].

Function:
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Subunit:
Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Expressed in all tissues examined.

Post-translational modifications:
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.

Similarity:
Belongs to the NF-kappa-B inhibitor family.
Contains 6 ANK repeats.

Database links:

Entrez Gene: 4793 Human

Entrez Gene: 18036 Mouse

Entrez Gene: 81525 Rat

Omim: 604495 Human

SwissProt: Q15653 Human

SwissProt: Q60778 Mouse

SwissProt: Q9JIA3 Rat

Unigene: 9731 Human

Unigene: 220333 Mouse

Unigene: 8395 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.