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Rabbit Anti-KMT5C/FITC Conjugated antibody

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  • Cat NO.:SL16799R-FITC
  • Product Spec:100ul
  • Clonality:Polyclonal
  • 100ul:496.00$
  • Price:$496
  • Total:
  • Quantity:
  • Manual

Goods Brief:

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Product Name Anti-KMT5C/FITC
Chinese Name FITC标记的组蛋白赖氨酸N-甲基5C抗体
Alias FLJ98627; Histone lysine N methyltransferase SUV420H2; KMT5C; Lysine N methyltransferase 5C; MGC2705; Su(var)4 20 homolog 2; SV422_HUMAN; Suppressor of variegation 4 20 homolog 2; Suv4 20h2; SUV420H2.  
Organism Species Rabbit
Clonality Polyclonal
React Species Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 52kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human KMT5C
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]

Function:
KMT5C/SUV4-20h2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. KMT5C/SUV4-20h2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions.

Subunit:
Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity). {ECO:0000250}.

Subcellular Location:
Nuclear.

Similarity:
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

Database links:

Entrez Gene: 84787 Human

Entrez Gene: 232811 Mouse

SwissProt: Q86Y97 Human

SwissProt: Q6Q783 Mouse

Unigene: 590982 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.