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Rabbit Anti-IPO11/FITC Conjugated antibody

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  • Cat NO.:SL16685R-FITC
  • Product Spec:100ul
  • Clonality:Polyclonal
  • 100ul:496.00$
  • Price:$496
  • Total:
  • Quantity:
  • Manual

Goods Brief:

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Product Name Anti-IPO11/FITC
Chinese Name FITC标记的RanBinding protein11抗体
Alias Imp11; Importin 11; Importin-11; IPO11; IPO11_HUMAN; Ran binding protein 11; Ran-binding protein 11; RanBP11; SLRN; Synleurin.  
Organism Species Rabbit
Clonality Polyclonal
React Species Human, Mouse, Rat, Dog, Horse, 
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 107kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human IPO11
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]

Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12.

Subcellular Location:
Cytoplasm. Nucleus.

Similarity:
Belongs to the importin beta family.
Contains 15 HEAT repeats.
Contains 1 importin N-terminal domain.

Database links:

Entrez Gene: 51194 Human

Entrez Gene: 76582 Mouse

Entrez Gene: 310056 Rat

Omim: 610889 Human

SwissProt: Q9UI26 Human

SwissProt: Q8K2V6 Mouse

Unigene: 482269 Human

Unigene: 132208 Mouse

Unigene: 482687 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.