TEL: 0086-571-56623320    EMAIL: SALES@SUNLONGBIOTECH.COM

Your Position: Home > Product Center > Antibody > Primary Antibodies > Rabbit Anti-HTRA3/Calpain 5 antibody

View History

Rabbit Anti-HTRA3/Calpain 5 antibody

prev next

  • Cat NO.:SL18100R
  • Product Spec:100ul
  • Clonality:Polyclonal
  • 100ul:263.00$
  • 200ul:413.00$
  • Price:$263
  • Total:
  • Quantity:
  • Manual

Goods Brief:

© 2005-2022 Elisa kit,Antibody-Sunlong Biotech Co.,Ltd Copyright, All Rights Reserved.
Product Name HTRA3/Calpain 5
Chinese Name 钙蛋白酶5抗体
Alias Calpain 5; Calpn 5; CAPN5; EC 3.4.21.; High temperature requirement factor A3; High-temperature requirement factor A3; HtrA serine peptidase 3; HTRA3; HTRA3_HUMAN; Pregnancy related serine protease; Pregnancy-related serine protease; Probable serine protease HTRA3; Probable serine protease HTRA3 precursor; PRSP; Serine protease HTRA3; Tasp.  
Organism Species Rabbit
Clonality Polyclonal
React Species Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
Applications WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 48kDa
Cellular localization Secretory protein 
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human HTRA3/Calpain 5:61-160/453 
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
Product Detail HtrA3 is a 453 amino acid secreted protein that contains one PDZ domain, one Kazal-like domain and one IGFBP N-terminal domain. Widely expressed with particularly high expression in ovary, heart, placenta and bladder, HtrA3 functions as a probable serine protease that is thought to play an important role in placental development. HtrA3 is downregulated in ovarian tumors, suggesting an alternative role in tumor suppression. HtrA3 exists as two alternatively spliced isoforms, designated short and long. The gene encoding HtrA3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Function:
Probable serine protease.

Subcellular Location:
Secreted.

Tissue Specificity:
Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney.

Similarity:
Belongs to the peptidase S1B family.
Contains 1 IGFBP N-terminal domain.
Contains 1 Kazal-like domain.
Contains 1 PDZ (DHR) domain.

SWISS:
P83110

Gene ID:
94031

Database links:

Entrez Gene: 94031 Human

Entrez Gene: 360959 Rat

Omim: 608785 Human

SwissProt: P83110 Human

SwissProt: D3ZA76 Rat

Unigene: 479119 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.