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Mouse Anti-PPT1 antibody

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  • Cat NO.:SLM51262M
  • Product Spec:50ul
  • Clonality:Monoclonal
  • 50ul:143.00$
  • 100ul:263.00$
  • Price:$143
  • Total:
  • Quantity:
  • Manual

Goods Brief:

Product Name PPT1
Chinese Name 小鼠抗棕榈酰蛋白硫酯酶1单克隆抗体
Alias CLN1; INCL; Palmitoyl protein hydrolase 1; Palmitoyl protein thioesterase 1; Palmitoyl-protein hydrolase 1; Palmitoyl-protein thioesterase 1; PPT; PPT-1; PPT1; PPT1_HUMAN.  
Organism Species Mouse
Clonality Monoclonal
克 隆 号 10G4
React Species Human, 
Applications WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:20-100 IHC-F=1:20-100 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 31kDa
Cellular localization cytoplasmic 
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human PPT1: 
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
Product Detail The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2008]

Function:
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748)

Subcellular Location:
Lysosome.

DISEASE:
Defects in PPT1 are the cause of neuronal ceroid lipofuscinosis type 1 (CLN1) [MIM:256730]. A form of neuronal ceroid lipofuscinosis with variable age at onset. Infantile, late-infantile, juvenile, and adult onset have been reported. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN1 is referred to as granular osmiophilic deposits (GROD).

Similarity:
Belongs to the palmitoyl-protein thioesterase family.

SWISS:
P50897

Gene ID:
5538

Database links:

Entrez Gene: 281421 Cow

Entrez Gene: 5538 Human

Entrez Gene: 19063 Mouse

Entrez Gene: 29411 Rat

Omim: 600722 Human

SwissProt: P45478 Cow

SwissProt: P50897 Human

SwissProt: O88531 Mouse

SwissProt: P45479 Rat

Unigene: 3873 Human

Unigene: 277719 Mouse

Unigene: 1574 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
 
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