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Mouse Anti-Cathepsin D antibody

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  • Cat NO.:SLM51237M
  • Product Spec:50ul
  • Clonality:Monoclonal
  • 50ul:143.00$
  • 100ul:263.00$
  • Price:$143
  • Total:
  • Quantity:
  • Manual

Goods Brief:

Product Name Cathepsin D
Chinese Name 小鼠抗组织蛋白酶D轻链抗体
Alias Cathepsin D light chain; CatD; CathepsinD; Cathepsin-D; CLN10; CPSD; CTSD; Lysosomal aspartyl peptidase; MGC2311; CATD_HUMAN.  
Organism Species Mouse
Clonality Monoclonal
克 隆 号 7B4
React Species Human, 
Applications WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:20-100 IHC-F=1:20-100 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 11/38/45kDa
Cellular localization cytoplasmic Secretory protein 
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen Recombinant human Cathepsin D: 
Lsotype IgG1
Purification affinity purified by Protein G
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
Product Detail Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease.

Function:
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

Subcellular Location:
Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Tissue Specificity:
Expressed in the aorta extrcellular space (at protein level).

Post-translational modifications:
N- and O-glycosylated.

DISEASE:
Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10); also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.

Similarity:
Belongs to the peptidase A1 family.

SWISS:
P07339

Gene ID:
1509

Database links:

Entrez Gene: 1509 Human

Entrez Gene: 13033 Mouse

Omim: 116840 Human

SwissProt: P07339 Human

SwissProt: P18242 Mouse

Unigene: 654447 Human

Unigene: 231395 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
 
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