Rabbit Anti-CLEC2A antibody_Elisa kit,Assay kit, Enzyme, Antibody-Sunlong Biotech Co.,Ltd

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Rabbit Anti-CLEC2A antibody

Cat NO.:SL20526R
Product Spec：100ul
Clonality：Polyclonal
100ul：418.00$
200ul：580.00$
Price:＄253
Total：
Quantity：
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Product Name CLEC2A

Chinese Name C型凝集素结构域家族2成员A抗体

Alias C-type lectin domain family 2 member A; CLC2A_HUMAN; CLEC2A; INPE5792; KACL; Keratinocyte-associated C-type lectin; PILAR; Proliferation-induced lymphocyte-associated receptor; UNQ5792.

Organism Species Rabbit

Clonality Polyclonal

React Species Human,

Applications ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

Molecular weight 20kDa

Cellular localization The cell membrane

Form Lyophilized or Liquid

Concentration 1mg/ml

immunogen KLH conjugated synthetic peptide derived from human CLEC2A:81-174/174 <Extracellular>

Lsotype IgG

Purification affinity purified by Protein A

Storage Buffer Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

Product Detail CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]

Function:
Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B lymphocytes and naive CD4(+) T cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.

Post-translational modifications:
N-glycosylated.

Similarity:
Contains 1 C-type lectin domain.

SWISS:
Q6UVW9

Gene ID:
387836

Database links:
Entrez Gene: 387836 Human

Omim: 612087 Human

SwissProt: Q6UVW9 Human

Unigene: 1087866 Human

Unigene: 527665 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Name	CLEC2A
Chinese Name	C型凝集素结构域家族2成员A抗体
Alias	C-type lectin domain family 2 member A; CLC2A_HUMAN; CLEC2A; INPE5792; KACL; Keratinocyte-associated C-type lectin; PILAR; Proliferation-induced lymphocyte-associated receptor; UNQ5792.
Organism Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	20kDa
Cellular localization	The cell membrane
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CLEC2A:81-174/174 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
Product Detail	CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008] Function: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. Subcellular Location: Cell membrane. Tissue Specificity: Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B lymphocytes and naive CD4(+) T cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells. Post-translational modifications: N-glycosylated. Similarity: Contains 1 C-type lectin domain. SWISS: Q6UVW9 Gene ID: 387836 Database links: Entrez Gene: 387836 Human Omim: 612087 Human SwissProt: Q6UVW9 Human Unigene: 1087866 Human Unigene: 527665 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.