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Rabbit Anti-CLEC2A antibody

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  • Cat NO.:SL20526R
  • Product Spec:100ul
  • Clonality:Polyclonal
  • 100ul:263.00$
  • 200ul:413.00$
  • Price:$263
  • Total:
  • Quantity:
  • Manual

Goods Brief:

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Product Name CLEC2A
Chinese Name C型凝集素结构域家族2成员A抗体
Alias C-type lectin domain family 2 member A; CLC2A_HUMAN; CLEC2A; INPE5792; KACL; Keratinocyte-associated C-type lectin; PILAR; Proliferation-induced lymphocyte-associated receptor; UNQ5792.  
Organism Species Rabbit
Clonality Polyclonal
React Species Human, 
Applications ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 20kDa
Cellular localization The cell membrane 
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human CLEC2A:81-174/174 <Extracellular>
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
Product Detail CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]

Function:
Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B lymphocytes and naive CD4(+) T cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.

Post-translational modifications:
N-glycosylated.

Similarity:
Contains 1 C-type lectin domain.

SWISS:
Q6UVW9

Gene ID:
387836

Database links:

Entrez Gene: 387836 Human

Omim: 612087 Human

SwissProt: Q6UVW9 Human

Unigene: 1087866 Human

Unigene: 527665 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.