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Cytochalasin A
Cytochalasin A, A metabolite of Drechslera dematoidea, can inhibit the growth and glucose transport of yeast strains. Cytorelaxin A is an oxidative analogue of cell protease B. Inhibit HIV-1 protease.
Alias: Dehydrophomin
Molecular formula: C29H35NO5, molecular weight: 477.59
Physical properties and indexes:
Appearance: …………………… White crystalline powder
Melting point: …………………… 190 ~ 191 ° C
Solubility: ………………… Soluble in DMSO(20mg/ml), ethanol (20mg/ml), insoluble in water.
Burning residue: ……………… < 0.1%
Purity: …………………… > 98%
Biological activity
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 ofDictyostelium, activating STATc.
Recommended solution preparation (for reference only)
Cytochalasin A is A solid crystalline powder, soluble in ethanol or DMSO, but difficult to dissolve in water. In order to enhance its solubility in water, cytochalasin A can be dissolved in DMF first, and then dissolved in water, the solubility of approximately 0.05mg/ml in 1:20 DMF/PBS.
Usage and Description:
Scientific research reagent
Storage conditions:
15 ~ 20 ° C
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